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DISIDA kinetics measure liver function in dogs.

I A Fraser1, P Shaffer, A E Staubus

  • 1Department of Surgery, Ohio State University, Columbus 43210.

Nuclear Medicine Communications
|June 1, 1989
PubMed
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99Tcm-disofenin (DISIDA) kinetics accurately measure liver function. Image analysis sensitively detects gradual liver recovery after biliary obstruction, outperforming blood data analysis.

Area of Science:

  • Hepatobiliary imaging
  • Nuclear medicine
  • Diagnostic radiology

Background:

  • Assessing liver function is crucial for diagnosing and managing hepatobiliary diseases.
  • Current methods for evaluating liver function may lack sensitivity in detecting subtle or gradual changes.
  • 99Tcm-disofenin (DISIDA) is a radiotracer used in nuclear medicine for hepatobiliary studies.

Purpose of the Study:

  • To investigate the efficacy of 99Tcm-disofenin (DISIDA) kinetics in quantifying liver function.
  • To compare quantitative analysis of serial liver images with whole blood clearance estimation for assessing liver dysfunction.
  • To evaluate the sensitivity of DISIDA kinetics in detecting gradual recovery of liver function following biliary obstruction.

Main Methods:

  • Induction of graded liver dysfunction in dogs via common bile duct ligation.

Related Experiment Videos

  • Quantitative kinetic analysis of serial liver images obtained after DISIDA injection.
  • Estimation of hepatic clearance from whole blood concentration-time data post-DISIDA injection.
  • Serial liver biopsies to correlate functional assessments with histological changes.

    • Main Results:

    • Kinetic analysis of liver images revealed significant abnormalities in uptake and elimination rates during biliary obstruction (p < 0.001 and p < 0.0001, respectively).
    • These parameters mirrored the decline and recovery of liver function, with incomplete recovery observed 7 weeks post-obstruction relief.
    • Whole blood clearance rates decreased significantly with obstruction (p < 0.001) and partially recovered post-relief, but image analysis showed more sensitive detection of gradual recovery.
    • Histological findings from liver biopsies corroborated the functional assessments, indicating persistent abnormalities after obstruction relief.

    Conclusions:

    • 99Tcm-disofenin (DISIDA) kinetics provide a valuable quantitative method for assessing liver function, capable of detecting both major and minor degrees of hepatic dysfunction.
    • Quantitative analysis of serial liver images is more sensitive than blood clearance data for identifying gradual recovery of liver function after biliary obstruction.
    • Hepatic abnormalities resulting from biliary obstruction exhibit slow recovery, underscoring the need for sensitive monitoring methods like DISIDA kinetic imaging.