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Updated: Mar 14, 2026

Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques
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Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques

Published on: July 5, 2018

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In Response to: 'Impact of Glycosylation on Effector Functions of Therapeutic IgG' (Pharmaceuticals 2010, 3, 146-157)

Andreas Nechansky1,2, Iris Koller3, Ralf Kircheis4,5

  • 1Meridian Biopharmaceuticals GmbH, Brunnerstrasse 59, 1230 Wien, Austria. a.nechansky@meridian-biopharm.at.

Pharmaceuticals (Basel, Switzerland)
|October 8, 2016
PubMed

To complete the review article by Abes and colleagues (Pharmaceuticals 2010, 3, 146-157) which provides a good overview on recently developed approaches for generation of glyco-modified antibodies and the impact of glyco-modification of antibodies on their effector functions, important information should be added, namely that - besides the Glycart and the Biowa approach to generate de-fucosylated antibodies - innovative, moss derived methods have been shown to generate glyco-modified antibodies with improved effector function profile.

Keywords:
ADCCCDCFc -γRIIIglyco-modified IgGtherapeutic antibodies

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