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Updated: Mar 14, 2026
09:11
Assays for Validating Histone Acetyltransferase Inhibitors
Published on: August 6, 2020
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Clinical Toxicities of Histone Deacetylase Inhibitors
Srividya Subramanian1, Susan E Bates2, John J Wright3
1TRI, Inc., 6500 Rock Spring Dr, Bethesda, MD 20817, USA. vsubramanian@tech-res.com.
Pharmaceuticals (Basel, Switzerland)
|October 8, 2016
Summary
Histone deacetylase (HDAC) inhibitors are novel antineoplastic agents with similar toxicity profiles, distinct from traditional chemotherapies. Further clinical studies are needed to manage their side effects and optimize combination therapies.
Area of Science:
- Oncology
- Pharmacology
Background:
- Histone deacetylase (HDAC) inhibitors represent a novel class of antineoplastic agents.
- These agents, despite diverse chemical structures and HDAC isoform specificities, exhibit remarkably similar toxicity profiles.
Approach:
- This review discusses the toxicity profiles of HDAC inhibitors in comparison to traditional cytotoxic chemotherapies and other epigenetic agents.
- It highlights the need to characterize long-term sequelae and potential toxicities in combination therapies.
Key Points:
- HDAC inhibitors share similar toxicity profiles, differing from conventional chemotherapy.
- Some side effects are novel, requiring oncologist awareness.
- Long-term effects and combination therapy toxicities require further investigation.
Conclusions:
- Limited phase 2 data necessitates more clinical experience to fully understand HDAC inhibitor side effect frequency and mitigation strategies.
- Distinguishing agent-specific toxicities is crucial for safe and effective cancer treatment.
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