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Related Experiment Video

Updated: Mar 14, 2026

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

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Published on: July 8, 2015

Striatal prediction errors support dynamic control of declarative memory decisions.

Jason M Scimeca^1,2, Perri L Katzman¹, David Badre^1,3

¹Department of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, Rhode Island 02912, USA.

Nature Communications

|October 8, 2016

Summary

This summary is machine-generated.

Prediction errors (PEs) from the striatum guide memory decisions by signaling deviations from expected outcomes. These signals, scaled by memory strength, influence and adapt memory retrieval strategies.

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Area of Science:

Neuroscience
Cognitive Psychology
Computational Psychiatry

Background:

Adaptive memory relies on context-dependent control of information retrieval and evaluation.
The neural signals driving adjustments in memory decisions are not well understood.

Purpose of the Study:

To investigate the role of prediction errors (PEs) in regulating memory decisions.
To identify the neural correlates of adaptive memory control.

Main Methods:

Human participants underwent a recognition memory test with biased feedback.
Model-based functional magnetic resonance imaging (fMRI) was used to analyze brain activity.
Behavioral experiments manipulated feedback to alter PEs and assessed criterion transfer.

Main Results:

Striatal activity correlated with PEs, defined as the deviation between expected and actual value of a memory decision.
Striatal PEs predicted individual differences in memory recognition criteria.
PEs were scaled relative to memory strength, not the expected trial outcome.
Learned recognition criteria transferred to free recall tasks.

Conclusions:

Striatal prediction errors are a key signal for adaptive control over memory decisions.
Reinforcement learning mechanisms, mediated by the striatum, regulate declarative memory.
These findings offer insights into the neural basis of memory regulation and adaptation.