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Calprotectin: Clinical Applications in Pediatrics.
Oscar R Herrera1, Michael L Christensen2, Richard A Helms2
1Department of Clinical Pharmacy, University of Tennessee Health Science Center College of Pharmacy, Memphis, Tennessee ; State of Tennessee Center of Excellence in Pediatric Pharmacokinetics and Therapeutics, Memphis, Tennessee.
Summary
Calprotectin is a valuable non-invasive biomarker for pediatric gastrointestinal inflammation. This review explores its use in various body fluids for monitoring inflammatory conditions in children.
Area of Science:
- Pediatric Gastroenterology
- Biomarker Research
- Clinical Diagnostics
Background:
- Calprotectin has emerged as a significant non-invasive biomarker for gastrointestinal (GI) inflammation over the last two decades.
- This review focuses on the application of calprotectin in pediatric populations, examining its utility across various disease states.
Approach:
- A comprehensive survey of published English-language studies on calprotectin in neonates, infants, children, and adolescents up to February 2014 was conducted.
- The review discusses calprotectin's fundamental properties, including its characteristics, identification, presence in bodily fluids, and developmental aspects.
- Evaluation of calprotectin's role in both GI and non-GI inflammatory conditions, with comparisons to existing serum markers, is presented.
Key Points:
- Calprotectin concentrations in diverse body fluids can effectively monitor inflammation in pediatric patients.
- The potential of calprotectin as a prospective marker for intestinal inflammation and readiness for feeding is explored.
- Comparative analysis highlights calprotectin's performance against other available serum markers for inflammatory diseases.
Conclusions:
- Calprotectin shows considerable promise as a monitoring tool in pediatric inflammatory conditions.
- Further research is needed to establish calprotectin as a routine clinical tool for monitoring intestinal inflammation and guiding therapeutic interventions.
- Prospective studies are essential to solidify calprotectin's role in clinical decision-making for pediatric GI health.
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