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Published on: March 30, 2019
The anti-cancer components of Ganoderma lucidum possesses cardiovascular protective effect by regulating circular RNA
Yi-Zhen Xie1,2, Fenghua Yang3, Weijiang Tan3
1State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangzhou, China.
Abstract:
To examine the role of oral Ganoderma spore oil in cardiovascular disease, we used transverse aortic constriction (TAC) in mice to model pressure overload-induced cardiomyopathy. Our preliminary results demonstrated a potential cardioprotective role for spore oil extracted from Ganoderma. We found that Ganoderma treatment normalized ejection fraction and corrected the fractional shortening generated by TAC. We also found evidence of reduced left ventricular hypertrophy as assessed by left ventricular end diastolic diameter. Analysis of total RNA expression using cardiac tissue samples from these mice corroborated our findings. We found reduced expression of genes associated with heart failure, including a novel circular RNA circ-Foxo3. Thus our data provides evidence for Ganoderma lucidum as a potential cardioprotective agent, warranting further preclinical exploration.
Insights
Oral Ganoderma spore oil shows cardioprotective effects in mice with heart failure. Ganoderma lucidum treatment improved heart function and reduced cardiac hypertrophy, suggesting potential for cardiovascular disease therapy.
Area of Science:
- Cardiovascular Science
- Pharmacology
- Molecular Biology
Background:
- Cardiovascular diseases remain a leading cause of mortality worldwide.
- Pressure overload-induced cardiomyopathy is a significant clinical challenge.
- Natural compounds are being explored for cardioprotective properties.
Purpose of the Study:
- To investigate the cardioprotective potential of oral Ganoderma spore oil.
- To evaluate the effects of Ganoderma on pressure overload-induced cardiomyopathy in a mouse model.
Main Methods:
- Utilized transverse aortic constriction (TAC) in mice to induce pressure overload-induced cardiomyopathy.
- Administered oral Ganoderma spore oil to the experimental group.
- Assessed cardiac function using ejection fraction and fractional shortening.
- Measured left ventricular hypertrophy via left ventricular end diastolic diameter.
- Analyzed cardiac gene expression, including novel circular RNA circ-Foxo3.
Main Results:
- Ganoderma treatment normalized ejection fraction and fractional shortening in TAC mice.
- Reduced left ventricular hypertrophy was observed in Ganoderma-treated mice.
- Decreased expression of heart failure-associated genes, including circ-Foxo3, was detected.
Conclusions:
- Oral Ganoderma spore oil demonstrates significant cardioprotective effects in a mouse model of pressure overload-induced cardiomyopathy.
- Ganoderma lucidum may serve as a potential therapeutic agent for cardiovascular diseases.
- Further preclinical studies are warranted to explore Ganoderma's cardioprotective mechanisms.
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