Developments toward the synthesis and application of 3-hydroxyindanones
Tanmoy Chanda1, Maya Shankar Singh1
1Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi-221005, India. mayashankarbhu@gmail.com.
Organic & Biomolecular Chemistry
|October 8, 2016
Summary
This review covers the synthesis and applications of 3-hydroxyindanone derivatives, crucial for drug discovery and materials science. It details total synthesis of natural products and highlights literature from 1948-2015.
Area of Science:
- Organic Chemistry
- Medicinal Chemistry
- Materials Science
Background:
- 3-Hydroxyindanone is a key structural motif in natural products, biologically active compounds, and functional materials.
- Its derivatives are vital for developing new pharmaceutical agents.
- Understanding the synthesis and applications of this scaffold is crucial for drug discovery.
Approach:
- This review comprehensively examines methods for constructing 3-hydroxyindanone derivatives.
- It discusses the total synthesis of complex natural products featuring this core structure.
- Literature from 1948 to 2015 is analyzed to provide historical context and key advancements.
Key Points:
- Detailed overview of synthetic strategies for 3-hydroxyindanone derivatives.
- Exploration of applications in pharmaceutically promising drug candidates.
- Case studies on the total synthesis of natural products incorporating the 3-hydroxyindanone core.
Conclusions:
- 3-Hydroxyindanone derivatives offer significant potential in medicinal chemistry and materials science.
- The synthetic methodologies and applications reviewed provide a foundation for future research.
- This work highlights the enduring importance of the 3-hydroxyindanone scaffold in chemical synthesis and drug development.
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