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Published on: August 13, 2019
Total synthesis of diptoindonesin G and its analogues as selective modulators of estrogen receptors
Ji-Tian Liu1, Truman J Do2, Christopher J Simmons3
1School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA and School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, P. R. China.
Abstract:
We have developed a versatile synthetic strategy for the synthesis of the natural product diptoindonesin G and its analogues as selective modulators of estrogen receptors. The strategy involves a regioselective dehydrative cyclization of arylacetals, a regioselective bromination of benzofurans, a sequential cross-coupling of bromo-benzofurans with aryl boronic acids, and a BBr3-mediated tandem cyclization and demethylation. Preliminary biological studies uncovered the critical and dispensable phenolic hydroxyl groups in the natural product and also revealed unexpected selectivity for isoforms of estrogen receptor.
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