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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Developing a self-healing supramolecular nucleoside hydrogel.

K J Skilling1, B Kellam1, M Ashford2

  • 1School of Pharmacy, University of Nottingham, NG7 2RD, UK. maria.marlow@nottingham.ac.uk.

Soft Matter
|October 8, 2016
PubMed
Summary

Researchers developed a novel self-healing nucleoside hydrogel for drug delivery. This biocompatible material shows promise for controlled release and exhibits excellent cell compatibility in vitro.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Low molecular weight gelator hydrogels offer tunable stability and biocompatibility, presenting an alternative to polymer-based drug delivery.
  • Developing novel hydrogel systems is crucial for advancing drug delivery platforms.

Purpose of the Study:

  • To report the first self-healing nucleoside hydrogel for drug delivery applications.
  • To characterize the hydrogel's structure and assess its in vitro drug delivery potential and cytocompatibility.

Main Methods:

  • Synthesis of N4-octanoyl-2'-deoxycytidine hydrogel at 0.5% (w/v).
  • Characterization using oscillatory rheology, Scanning Electron Microscopy (SEM), and Transmission Electron Microscopy (TEM).
  • In vitro drug delivery studies with fluorescently labeled tracers and cell viability assays on pancreatic and fibroblast cell lines.

Main Results:

  • Successful formation of a self-healing nucleoside hydrogel with a cross-linked nanofibrillar structure.
  • Demonstrated potential for drug delivery applications through in vitro tracer studies.
  • Excellent cytocompatibility observed, with no adverse effects on pancreatic or fibroblast cell viability and proliferation.

Conclusions:

  • N4-octanoyl-2'-deoxycytidine hydrogels represent a promising new class of self-healing biomaterials for drug delivery.
  • The hydrogel's biocompatibility and structural integrity support its potential use in therapeutic applications.
  • Further research into this nucleoside hydrogel platform could lead to innovative drug delivery solutions.