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Aggressive esthesioneuroblastoma with divergent differentiation: A taxonomic dilemma
Norman C Charles1,2, Carisa K Petris1, Eleanore T Kim1
1a Department of Ophthalmology , New York University Langone Medical Center , New York , New York , USA.
Abstract:
The authors describe an esthesioneuroblastoma (olfactory neuroblastoma) that occurred within the nasal cavity and brain in a 31-year-old man. Following excision, the tumor recurred in the left orbit and in mediastinal lymph nodes. Treatment included orbital excision and systemic chemotherapy. Histopathology showed a high-grade neuroepithelial tumor with positive immunohistochemical markers for neuroendocrine and epithelial components, an unusual combination raising issues concerning taxonomy.
