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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Small dense low-density lipoprotein cholesterol was associated with future cardiovascular events in chronic kidney

Hao Shen1, Yan Xu2, Jingfen Lu3

  • 1Department of Clinical Laboratory Medicine, First People's Hospital of Wujiang District, Nantong University, Suzhou, China. shenhaojyk@126.com.

BMC Nephrology
|October 8, 2016
PubMed

Insights

For patients with chronic kidney disease (CKD), elevated small low-density lipoprotein cholesterol (sdLDL-C) is a significant risk factor for cardiovascular disease (CVD). This study confirms a strong link between higher sdLDL-C levels and increased CVD events in CKD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Clinical Chemistry

Background:

  • Cardiovascular disease (CVD) frequently co-occurs with chronic kidney disease (CKD).
  • Small low-density lipoprotein cholesterol (sdLDL-C) is an emerging risk factor for CVD.
  • The relationship between sdLDL-C and CVD in CKD patients requires further investigation.

Purpose of the Study:

  • To investigate the association between sdLDL-C concentration and the incidence of cardiovascular events in patients with CKD.
  • To identify sdLDL-C as a potential biomarker for CVD risk in CKD.

Main Methods:

  • Retrospective analysis of 145 patients with Stage 3 and Stage 4 CKD.
  • Measurement of sdLDL-C concentrations between 2010 and 2012.
  • Four-year follow-up to record cardiovascular events (fatal and nonfatal).
  • Multivariate Cox regression and Kaplan-Meier survival analyses were employed.

Main Results:

  • A total of 54 cardiovascular events (8 fatal, 46 nonfatal) were recorded during follow-up.
  • Elevated sdLDL-C (hazard ratio [HR] 1.278, 95% CI [1.019-1.598]) and sdLDL-C/LDL-C ratio (HR 2.456, 95% CI [1.421-15.784]) were independent predictors of cardiovascular events.
  • Patients with sdLDL-C >38 mg/dl and sdLDL-C/LDL-C ratio >0.3 showed significantly increased risk for cardiovascular events (P<0.05).

Conclusions:

  • Elevated sdLDL-C concentration is significantly associated with an increased risk of cardiovascular disease in patients with CKD.
  • sdLDL-C may serve as a valuable marker for assessing cardiovascular risk in the CKD population.
  • Further research is warranted to explore therapeutic strategies targeting sdLDL-C in CKD patients.
Abstract

Keywords:
Cardiovascular diseasesChronic kidney diseaseLipidssdLDL-C

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