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Pseudomonas mendocina native valve infective endocarditis: a case report
Glenn J Rapsinski1, Jina Makadia2, Nitin Bhanot2
1Temple University School of Medicine, Philadelphia, PA, USA.
Journal of Medical Case Reports
|October 8, 2016
Summary
This study reports the first case of native valve infective endocarditis caused by Pseudomonas mendocina in the USA. All patients with this rare infection experienced favorable outcomes, highlighting effective treatment with third-generation cephalosporins.
Area of Science:
- Infectious Diseases
- Bacteriology
- Cardiology
Background:
- Gram-negative bacteria are uncommon causes of infective endocarditis.
- Pseudomonas mendocina, a rare pathogen, has been infrequently reported since 1992.
- This study details the first US case of native valve infective endocarditis caused by P. mendocina.
Observation:
- A 57-year-old male with leg ulcers and chronic alcohol use presented with fever and leukocytosis.
- Blood cultures identified P. mendocina, leading to echocardiography revealing mitral valve endocarditis.
- A literature review identified eight cases of P. mendocina infection, with most linked to native valve endocarditis.
Findings:
- Pseudomonas mendocina bacteremia originated from leg wounds in this patient.
- P. mendocina is susceptible to third-generation cephalosporins, unlike Pseudomonas aeruginosa.
- All reported P. mendocina infective endocarditis cases affected native valves, predominantly left-sided, with favorable outcomes.
Implications:
- This case expands the understanding of rare bacterial causes of infective endocarditis.
- Effective antibiotic regimens, including third-generation cephalosporins, are crucial for P. mendocina infections.
- The favorable outcomes in all reported cases suggest good prognosis with appropriate treatment.
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