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Published on: June 5, 2019
Mean platelet volume in children with hepatitis A
Fatih Akın1, Ahmet Sert2, Şükrü Arslan3
1Department of Pediatrics, Necmettin Erbakan University, Meram Medical Faculty, 42080, Konya, Turkey. drfatihakin@gmail.com.
Insights
Mean platelet volume (MPV) was elevated in children with hepatitis A. MPV levels decreased after treatment but remained higher than in healthy children.
Area of Science:
- Pediatric Gastroenterology
- Hematology
- Infectious Diseases
Background:
- Mean platelet volume (MPV) reflects platelet production and activation.
- Hepatitis A is a common childhood infection.
- The role of MPV in pediatric hepatitis A is not well understood.
Purpose of the Study:
- To investigate MPV levels in children diagnosed with hepatitis A.
- To compare MPV in children with hepatitis A to healthy controls.
Main Methods:
- Retrospective case-controlled study.
- Included 62 children with hepatitis A and 62 healthy controls.
- Analyzed MPV, white blood cell (WBC) counts, aspartate transaminase (AST), and alanine transaminase (ALT) levels.
Main Results:
- Children with hepatitis A had significantly higher MPV, AST, and ALT levels, and lower WBC counts compared to controls.
- MPV levels decreased after two weeks but remained elevated compared to controls.
- Significant differences in MPV, WBC, AST, and ALT persisted between groups after two weeks.
Conclusions:
- This is the first study to report elevated MPV in children with hepatitis A.
- Increased MPV may serve as a potential indicator in pediatric hepatitis A.
Background:
Mean platelet volume (MPV), which is commonly used as a measure of platelet size, indicates the rate of platelet production and platelet activation. We aimed to evaluate the mean platelet volume in children with hepatitis A.
Methods:
In this retrospective case-controlled study, the study population consisted of 62 children with hepatitis A and 62 healthy control subjects.
Results:
MPV values, aspartate transaminase (AST), and alanine transaminase (ALT) levels on admission were significantly increased in patients with hepatitis A when compared to controls whereas white blood cell (WBC) counts were significantly lower. Two weeks after admission, the MPV values showed a significant decrease from 9.47 ± 1.62 to 8.84 ± 1.48 fL in patients with hepatitis A, but these values were still significantly higher than the controls. There was a significant difference in terms of MPV, WBC, AST, and ALT values between the controls and the patient group 2 weeks after admission.
Conclusions:
This study is the first to evaluate the MPV levels in children with hepatitis A. MPV values were found to be increased in children hospitalized with hepatitis A.
