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Updated: Mar 14, 2026

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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
3.8K
Immediate postpartum mood assessment and postpartum depressive symptoms
Michelle L Miller1, Emily B Kroska1, Rebecca Grekin1
1University of Iowa, United States.
Journal of Affective Disorders
|October 8, 2016
Summary
Early postpartum negative affect (NA) and positive affect (PA) predict depressive symptoms. Measuring affect shortly after birth can identify women at higher risk for postpartum depression, enabling timely intervention.
Area of Science:
- Perinatal mental health
- Psychiatry
- Obstetrics
Background:
- Postpartum depressive symptoms are a significant concern.
- The role of early postpartum negative affect (NA) and positive affect (PA) in predicting these symptoms requires further clarification.
- Existing research has not fully elucidated the relationship between immediate postpartum affect and subsequent depressive symptoms.
Purpose of the Study:
- To investigate if NA and PA in the immediate postpartum period predict postpartum depressive symptoms.
- To determine if these affective states predict depressive symptoms independently of established risk factors like previous trauma and depression history.
- To enhance understanding of early indicators for postpartum depression risk.
Main Methods:
- Prospective recruitment of 526 participants from a Mother-Baby Unit.
- Assessment of NA and PA using the Daily Experiences Questionnaire (DEQ) within three days postpartum.
- Tracking of depressive symptoms at two and twelve weeks postpartum via self-report.
Main Results:
- Low PA and high NA immediately postpartum significantly predicted depressive symptoms at both two and twelve weeks.
- These affective measures remained significant predictors even when controlling for prior trauma and depression history.
- The findings highlight the predictive power of early postpartum emotional states.
Conclusions:
- Negative affect and positive affect in the early postpartum period are significant predictors of later depressive symptoms.
- Early assessment of maternal affect in hospitals may serve as a valuable tool for identifying at-risk individuals.
- This approach can facilitate timely prevention and early intervention strategies for postpartum depression.
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