Bone mineral density is associated with left ventricular diastolic function in women

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Rui-Tao Wang1, Xue-Song Li2, Ji-Rong Zhang3

  • 1Department of Internal Medicine, Third Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.

Clinical Cardiology
|October 8, 2016
PubMed

Insights

Osteoporosis is linked to impaired heart function in women. Lower bone mineral density (BMD) correlates with poorer left ventricular (LV) diastolic function, suggesting a connection between bone health and cardiac health.

Area of Science:

  • Cardiology
  • Endocrinology
  • Gerontology

Background:

  • Low bone mineral density (BMD) and left ventricular (LV) diastolic dysfunction are risk factors for heart failure.
  • The relationship between BMD and LV diastolic function remains unclear.

Purpose of the Study:

  • To investigate the association between BMD and LV diastolic function in women.
  • To determine if BMD is an independent predictor of LV diastolic dysfunction.

Main Methods:

  • Cross-sectional study of 432 women.
  • Assessment of BMD, brachial-ankle pulse wave velocity (baPWV), and LV diastolic function via echocardiography.
  • Statistical analysis including partial correlation and multivariate logistic regression.

Main Results:

  • Progressive bone loss was associated with increased baPWV and LV diastolic dysfunction.
  • BMD at the spine and femoral neck correlated with baPWV and LV diastolic parameters.
  • Osteoporosis was an independent predictor of LV diastolic dysfunction in women.

Conclusions:

  • Osteoporosis is independently associated with LV diastolic dysfunction in women.
  • Further prospective research is warranted to explore the impact of BMD on cardiac function.
Abstract

Keywords:
Imagingechocardiography

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