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Updated: Mar 14, 2026
Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis
Published on: October 4, 2024
Evaluation of an ultra-low-dose oral contraceptive for dysmenorrhea: a placebo-controlled, double-blind, randomized
Tasuku Harada1, Mikio Momoeda2
1Department of Obstetrics and Gynecology, Tottori University School of Medicine, Tottori, Japan.
Objective:
To evaluate the efficacy and safety of an ultra-low-dose oral contraceptive (NPC-01; 0.02 mg ethinyl estradiol and 1 mg norethisterone) in subjects with dysmenorrhea.
Design:
Placebo-controlled, double-blind, randomized trial.
Setting:
Clinical trial sites.
Patient(S):
Two hundred fifteen subjects with dysmenorrhea.
Intervention(S):
Subjects were randomly assigned to receive NPC-01, placebo, or IKH-01 (0.035 mg ethinyl estradiol and 1 mg norethisterone) for four cycles.
Main Outcome Measure(S):
Total dysmenorrhea score (verbal rating scale) assessing pain on the basis of limited ability to work and need for analgesics.
Result(S):
The reductions of total dysmenorrhea score and visual analog scale score after the treatment were significantly higher in the NPC-01 group than in the placebo group. Furthermore, the efficacy of NPC-01 was comparable to that of IKH-01. The overall incidence of side effects was significantly higher in the NPC-01 group than in the placebo group. All side effects that occurred in the NPC-01 group were previously reported in patients receiving IKH-01. No serious side effects occurred.
Conclusion(S):
The ultra-low-dose contraceptive NPC-01 relieved dysmenorrhea as effectively as IKH-01. Thus, NPC-01 could represent a new option for long-term treatment of dysmenorrhea.
Clinical Trial Identification Number:
NCT01129102.
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