Related Experiment Video
Updated: Mar 14, 2026
10:34
A High-content Assay for Monitoring AMPA Receptor Trafficking
Published on: January 28, 2019
8.1K
The LGI1-ADAM22 protein complex in synaptic transmission and synaptic disorders
Yuko Fukata1, Norihiko Yokoi1, Yuri Miyazaki1
1Division of Membrane Physiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki 444-8787, Japan; Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Okazaki 444-8787, Japan.
Neuroscience Research
|October 9, 2016
Summary
The LGI1-ADAM22 complex is crucial for brain function and synaptic transmission. Dysregulation of this complex is linked to epilepsy and memory loss, highlighting its role in neurological disorders.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Synaptic transmission is vital for brain function; its disruption underlies disorders like autism, dementia, and epilepsy.
- Key regulators of synaptic function, including disease-related proteins like neurexin-neuroligin and NMDA receptors, are critical research targets.
Purpose of the Study:
- To review current knowledge on the LGI1-ADAM22 ligand-receptor complex.
- To discuss the roles of LGI1 and ADAM22 in synaptic transmission and associated disorders.
Main Methods:
- Literature review of basic and clinical research on LGI1 and ADAM22.
- Analysis of genetic mutations and autoantibody associations with neurological conditions.
Main Results:
- Mutations in the LGI1 gene are associated with autosomal dominant lateral temporal lobe epilepsy.
- Autoantibodies against LGI1 cause limbic encephalitis, leading to memory loss and seizures.
Conclusions:
- The LGI1-ADAM22 complex plays a significant role in synaptic transmission and overall brain function.
- Understanding LGI1-ADAM22 is essential for developing therapeutic strategies for epilepsy and limbic encephalitis.
More Related Videos
Related Concept Videos
01:30Ligand-Gated Ion Channel Receptor: Gating Mechanism
4.5K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
4.5K
01:03Long-term Depression
3.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
3.5K
01:05Long-term Depression
33.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.6K
01:19Ligand-gated Ion Channels
15.1K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
15.1K
01:26Chemical Synapses
6.8K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
6.8K
01:26Chemical Synapses
12.3K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
12.3K