Related Experiment Video

Updated: Mar 14, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

22.2K

Predicting postoperative morphine consumption in children

Vilnis Silins1, Christopher Brasher1, Freedom Antus1

  • 1Department of Anaesthesia, Intensive care, Robert-Debré University Hospital, Paris Diderot University, Paris Sorbonne Cité, Paris, France.

Anaesthesia, Critical Care & Pain Medicine
|October 9, 2016
PubMed

Insights

Younger age, female gender, longer surgery, and higher initial morphine doses predict higher postoperative morphine needs in children. This helps manage pediatric pain effectively.

Area of Science:

  • Pediatric Anesthesiology
  • Pain Management
  • Pharmacokinetics

Background:

  • Morphine is a primary analgesic for moderate to severe postoperative pain in children.
  • Limited research exists on factors predicting morphine consumption in pediatric surgical patients.
  • Accurate prediction of analgesic needs is crucial for effective pain management.

Purpose of the Study:

  • To identify predictors of postoperative morphine consumption in pediatric surgical patients.
  • To develop and validate a statistical model for predicting morphine requirements.

Main Methods:

  • Prospective enrollment of pediatric surgical patients receiving morphine postoperatively.
  • Data collection included morphine consumption, patient demographics, surgery details, and pain intensity.
  • Statistical analysis involved univariate and multivariate linear regression to build and validate a predictive model.

Main Results:

  • Multivariate analysis identified younger age, female gender, longer surgery duration, and higher initial morphine titration as significant predictors.
  • The developed model explained 57% of the variability in total morphine consumption by postoperative day 3.
  • The model showed significant correlation between observed and predicted morphine values in the validation cohort (r=0.67, P<0.0001).

Conclusions:

  • Age, gender, surgery duration, and initial morphine titration are strong predictors of 3-day postoperative morphine consumption in children.
  • This predictive model can assist clinicians in optimizing postoperative pain management for pediatric surgical patients.
  • Understanding these factors enables better anticipation and control of analgesic requirements.
Abstract

Keywords:
MorphinePaediatricPainPostoperativeSurgery

More Related Videos

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats04:11

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats

Published on: November 6, 2018

17.9K
Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities07:23

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Published on: July 29, 2014

34.3K

Related Concept Videos

Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
1.3K
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
1.3K
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
950
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
2.7K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
673
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
861