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Updated: Mar 14, 2026
Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
Published on: April 27, 2016
[Definitions destruction of endothelial cells as a marker of endothelial dysfunction in aging men]
Ганна Л Пустовойт1, Тетяна І Ярмола1, Олександр В Мохначов1
1Вищий державний навчальний заклад України ≪Українська медична стоматологічна академія ≫, Полтава, Україна.
Insights
Aging men with diabetes and hypertension show increased endothelial damage. Addressing hormonal balance and lipid metabolism is key to reducing cardiovascular risk in these individuals.
Area of Science:
- Cardiovascular Research
- Endocrinology
- Gerontology
Background:
- Cardiovascular diseases are the leading cause of death in Ukraine, with endothelium dysfunction playing a critical role.
- Ukraine faces significant challenges in life expectancy and mortality rates, highlighting the need for research into cardiovascular health.
Purpose of the Study:
- To investigate endothelial destruction in aging men by measuring specific endothelial microparticle antigens.
- To assess the relationship between type 2 diabetes mellitus (DM-2), arterial hypertension (AH), and endothelial dysfunction in aging men.
Main Methods:
- Study involved 88 men aged 45-76, divided into a main group (50 with DM-2 and AH) and a control group (38 without these conditions).
- Participants were further categorized by age into 45-59 years and over 60 years groups.
- Endothelial microparticle levels and lipid profiles were analyzed.
Main Results:
- Elevated endothelin levels were observed in aging men with DM-2 and AH compared to controls across both age groups.
- Higher endothelin and triglyceride levels were found in older men (over 60) with DM-2 and AH compared to younger men in the main group.
- These findings indicate significant endothelial damage associated with comorbidities in aging men.
Conclusions:
- Age-related androgen deficiency contributes to lipid metabolism disorders, endothelial dysfunction, insulin resistance, diabetes, and hypertension.
- Reducing cardiovascular risk requires interventions targeting hormonal balance and lipid metabolism in aging men with DM-2 and hypertension.
- Endothelial microparticle analysis serves as a valuable marker for assessing cardiovascular risk.
Introduction:
Ukraine occupies the 143 place in the world in life expectancy and the first place in terms of mortality. The main cause of death - cardiovascular diseases - 58%. Recent studies show the important and independent role of endothelium in the development of cardiovascular disease.
The Aim:
examination of the endothelium destruction in aging men by determining the level of surface specific antigens of endothelial microparticles.
Materials And Methods:
88 men age from 45 to 76 years. 50 people of the main group had a history of the second type diabetes mellitus (DM-2) combined with arterial hypertension (AH). The control group included 38 men without aforementioned diseases. Also, men were divided into two groups by age: 45-59 years and over 60.
Results:
in the main subgroup I endothelin level was higher than the control subgroup I: 2,07 ± 0,6 and 1,27 ± 0,25 (p <0.05). In main subgroup II endothelin level was also significantly higher compared with the specified index in control subgroup II: 3,91 ± 0,7 and 1,79 ± 0,27 (p <0.05). Among patients of the main subgroup II endothelin level (3,88 ± 0,7 and 2,04 ± 0,6 (p <0.05)), and triglycerides (2,77 ± 0,08 vs. 1.99 ± 0.05 (p <0.05)) was higher compared with the I subgroup.
Conclusions:
age androgen deficiency is accompanied by lipid metabolism, development of endothelial dysfunction, insulin resistance, diabetes and hypertension. Reduction of the cardiovascular risk includes measures aimed at normalizing hormonal balance and lipid metabolism in aging men with DM-2 and hypertension.
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