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Donkin psychosis.

Ian Brockington1

  • 1University of Birmingham, Edgbaston, Birmingham,, B15 2TT, UK. I.F.BROCKINGTON@bham.ac.uk.

Archives of Women'S Mental Health
|October 9, 2016
PubMed
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Donkin psychoses, a type of eclamptic psychosis without seizures, stem from cerebral endothelial damage. These conditions, often seen in first-time mothers during pregnancy or postpartum, typically resolve fully.

Area of Science:

  • Neurology
  • Obstetrics
  • Psychiatry

Background:

  • Eclamptic psychoses are severe mental disturbances associated with eclampsia.
  • Lucid intervals between eclampsia and psychosis suggest underlying cerebral pathology.
  • Donkin psychoses represent a specific presentation of eclamptic psychosis.

Purpose of the Study:

  • To define Donkin psychoses as eclamptic psychoses occurring without seizures.
  • To explore the pathophysiological basis of Donkin psychoses, linking them to cerebral endothelial damage.
  • To highlight the diagnostic significance of Donkin psychoses in childbearing women.

Main Methods:

  • Clinical case review and literature synthesis.
  • Differential diagnosis of postpartum and antepartum psychoses.
Keywords:
Donkin psychosisEclamptic psychosisLucid intervalsSeizures

Related Experiment Videos

  • Pathophysiological correlation with cerebral endothelial damage.

    • Main Results:

    • Donkin psychoses are characterized by the absence of seizures, differentiating them from typical eclamptic psychosis.
    • These psychoses manifest during pregnancy or the puerperium, particularly in primiparous women.
    • Clinical presentations include delirium and mania, with potential for cognitive deficits like retrograde amnesia.

    Conclusions:

    • Donkin psychoses are symptomatic psychoses resulting from cerebral endothelial damage, explaining inter-episode lucidity in eclampsia.
    • They share features with eclamptic psychoses but lack seizures.
    • Consideration of Donkin psychoses is crucial in the differential diagnosis of psychoses during the childbearing period.