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Mitochondrial Changes in Cancer.

Shubha Gururaja Rao1

  • 1Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, 19102, USA. shubha.gururajarao@drexelmed.edu.

Handbook of Experimental Pharmacology
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PubMed
Summary

Mitochondria are crucial for cell health and metabolism. Cancer cells exhibit altered mitochondria, impacting their survival, proliferation, and resistance to cell death, making them a key therapeutic target.

Keywords:
ApoptosisCancerMitochondriaMitochondrial fissionMitochondrial fusionReactive oxygen species

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Area of Science:

  • Cell Biology
  • Biochemistry
  • Oncology

Background:

  • Mitochondrial integrity regulates cellular metabolism, proliferation, and apoptosis.
  • Cancer cells display altered metabolism, including the Warburg effect and resistance to apoptosis.
  • Mitochondrial dysfunction is implicated in cancer development and progression.

Purpose of the Study:

  • To summarize mitochondrial alterations in cancer.
  • To discuss the role of mitochondria in tumorigenesis.
  • To review mitochondria as a therapeutic target in cancer treatment.

Main Methods:

  • Literature review of mitochondrial changes in cancer.
  • Analysis of the relationship between mitochondria, Warburg effect, and cancer metabolism.
  • Exploration of mitochondrial gene mutations and biogenesis in cancer.

Main Results:

  • Mitochondria exhibit structural and functional variations in cancer cells.
  • Cancer cells possess altered metabolic pathways and resistance to apoptosis.
  • Mitochondrial targeting is a promising strategy in cancer pharmacology.

Conclusions:

  • Mitochondrial behavior is significantly altered during tumorigenesis.
  • Understanding these changes is vital for developing novel cancer therapies.
  • Targeting mitochondria offers a potential avenue for reducing tumor proliferation.