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Diverse roles of miR-335 in development and progression of cancers

Long-Ji Luo1,2, Dan-Dan Wang2,3, Jing Wang2,3

  • 1Department of General Surgery, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|October 9, 2016
PubMed

Insights

MicroRNA-335 (miR-335) is crucial in cancer development and progression. This review explores miR-335

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression post-transcriptionally.
  • Dysregulation of miRNA-335 (miR-335) is implicated in human cancers, affecting tumorigenesis and progression.
  • Understanding miR-335's role is vital for cancer research.

Approach:

  • This review summarizes mechanisms regulating miR-335 expression in various cancers.
  • It analyzes target genes and downstream signaling pathways influenced by miR-335.
  • The study correlates miR-335 expression with clinical tumor characteristics and patient prognosis.

Key Points:

  • miR-335 regulates genes involved in tumor growth, invasion, and metastasis.
  • miR-335 expression levels correlate with clinical tumor features.
  • Evidence suggests miR-335 impacts patient prognosis in cancer.

Conclusions:

  • miR-335 plays a significant role in cancer biology.
  • miR-335 shows potential as a biomarker for cancer diagnosis and prognosis.
  • Therapeutic strategies targeting miR-335 are promising for cancer treatment.
Keywords:
BiomarkerCancersMiR-335MicroRNA

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