Morphine treatment and intravenous glucose tolerance tests in mice

The effect of acute and chronic morphine treatment on i.v. glucose tolerance tests in mice was investigated. It was found that neither acute nor chronic morphine treatment affected the serum glucose disappearance with time after i.v. glucose loading, indicating that morphine has no significant effect on glucose tolerance. Analysis of hepatic glycogen and glucose levels in these mice revealed that morphine treatment might have some effects on glucose metabolism, but at the analgesic dose employed, did not impair the animal's physiological response to i.v. glucose loading.