Functional dystonia

Although currently lacking a sensitive and specific electrophysiologic battery test, functional (psychogenic) dystonia can sometimes be diagnosed with clinically definite certainty using available criteria. Certain regional phenotypes have been recognized as distinctive, such as unilateral lip and jaw deviation, laterocollis with ipsilateral shoulder elevation and contralateral shoulder depression, fixed wrist and finger flexion with relative sparing of the thumb and index fingers, and fixed foot plantar flexion and inversion. The pathophysiologic abnormalities in functional dystonia overlap substantially with those of organic dystonia, with similar impairments in cortical and spinal inhibition and somatosensory processing, but with emerging data suggesting abnormalities in regional blood flow and activation patterns on positron emission tomography and functional magnetic resonance imaging, respectively. Management of functional dystonia begins with compassionate and assertive debriefing of the diagnosis to ensure full acceptance by the patient, a critical step in enhancing the likelihood of success with physical rehabilitation, and psychodynamic or cognitive therapy. Physical therapy, with or without cognitive behavioral therapy, appears to be of benefit but has not yet been examined in a controlled fashion. While the prognosis remains grim for a substantial majority of patients, partly stemming from restricted mobility, delayed diagnosis, and inappropriate pharmacotherapy, early recognition and initiation of therapy stand to minimize iatrogenic harm and unnecessary laboratory investigations, and potentially reduce the long-term neurologic disability.