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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
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Related Experiment Video

Updated: Mar 13, 2026

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Circadian-Time Sickness: Time-of-Day Cue-Conflicts Directly Affect Health.

Raymond van Ee1, Sander Van de Cruys2, Luc J M Schlangen3

  • 1Laboratory of Experimental Psychology, KU Leuven, Leuven, Belgium; Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands; Philips Research, Department Brain, Behavior and Cognition, Eindhoven, The Netherlands.

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Disrupted daily rhythms, common in jetlag and shift work, can now be explained by a new theory. This research proposes that desynchronization between internal and environmental time cues causes

Keywords:
circadian rhythmcircadian sicknesscue-conflict theorynormative principlesprobability theory

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Area of Science:

  • Neuroscience
  • Chronobiology
  • Theoretical Biology

Background:

  • Disruptions in daily biological rhythms (e.g., jetlag, shift work) negatively impact mood and health via unknown neural pathways.
  • The brain's biological clock, or pacemaker, integrates environmental and internal time cues.

Purpose of the Study:

  • To propose a novel theoretical framework explaining the health consequences of circadian rhythm desynchronization.
  • To link cue-conflict theory with the neurophysiology of the biological clock.

Main Methods:

  • Combined Bayesian probabilistic 'cue-conflict' theory with established biological clock physiology.
  • Modeled the biological clock as two interacting units representing environmental and internal time cues.

Main Results:

  • Demonstrated that a functional biological clock requires only two interacting units, not a central director.
  • Identified desynchronization between ventral (environmental) and dorsal (internal) pacemaking signals as a result of unnatural light-dark cycles.

Conclusions:

  • This desynchronization, termed 'circadian-time sickness', is proposed as the direct cause of health issues.
  • Circadian-time sickness is analogous to motion sickness, arising from conflicting sensory inputs.