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Updated: Mar 13, 2026

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

Bone Marrow Aspirate Evaluation.

Nicole I Stacy¹, John W Harvey²

¹Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, 2015 Southwest 16th Avenue, Gainesville, FL 32610, USA.

The Veterinary Clinics of North America. Small Animal Practice

|October 11, 2016

Summary

This summary is machine-generated.

Accurate bone marrow aspirate evaluation is crucial for diagnosing hematologic disorders. Key steps include proper collection, preparation, and systematic cytologic assessment alongside complete blood counts.

Keywords:

Bone marrow Cat Cytology Dog Evaluation Interpretation

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Area of Science:

Hematology
Cytopathology

Background:

Bone marrow aspirate evaluation is a critical diagnostic tool.
Accurate interpretation requires understanding cell morphology and proportions.

Purpose of the Study:

To outline essential components for effective bone marrow aspirate evaluation.
To emphasize the importance of a systematic approach in cytologic assessment.

Main Methods:

Systematic cytologic evaluation of bone marrow aspirates.
Assessment of bone marrow cell morphology and proportions.
Correlation with complete blood cell count findings.

Main Results:

Proper collection, smear preparation, and staining are vital.
Knowledge of normal bone marrow cell types and their proportions is necessary.
Evaluation of cellularity and correlation with CBC are pillars of diagnosis.

Conclusions:

A systematic approach to bone marrow aspirate evaluation is essential for accurate diagnosis.
Integration of cytologic findings with complete blood cell counts enhances diagnostic utility.
Mastery of these components maximizes the information gained for hematologic disorder diagnosis.