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Myocardial Fibrosis in Athletes
Freek R van de Schoor1, Vincent L Aengevaeren1, Maria T E Hopman1
1Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Mayo Clinic Proceedings
|October 11, 2016
Summary
Myocardial fibrosis (MF) can occur in athletes, potentially linked to intense exercise. Further research is needed to understand its causes and clinical implications in athletic populations.
Area of Science:
- Cardiology
- Sports Medicine
- Pathology
Background:
- Myocardial fibrosis (MF) is a significant predictor of sudden cardiac death in various cardiac conditions.
- While regular exercise benefits cardiovascular health, intense training may paradoxically lead to pathological cardiac remodeling and MF.
- The presence and clinical significance of MF in athletes remain largely unknown.
Purpose of the Study:
- To systematically review the existing literature on myocardial fibrosis in athletes.
- To identify the prevalence, location, and potential contributing factors of MF in this population.
- To discuss the clinical implications and possible therapeutic strategies for MF in athletes.
Main Methods:
- A comprehensive systematic literature search was conducted using PubMed and MEDLINE databases up to June 2016.
- Search terms included Medical Subject Headings and keywords related to myocardial fibrosis and exercise training.
- Studies reporting primary MF data in athletes were included, encompassing case studies, series, and athletic population studies.
Main Results:
- A total of 65 athletes with MF were identified across 19 case studies/series and 14 athletic population studies.
- MF in athletes was predominantly observed in the intraventricular septum and the junction of the right ventricle with the septum.
- Potential contributing factors identified include genetic predisposition, silent myocarditis, pulmonary artery pressure overload, and exercise-induced micro-injury.
Conclusions:
- Myocardial fibrosis is a documented finding in athletes, particularly in specific cardiac regions.
- The exact mechanisms driving MF development in athletes require further investigation.
- Understanding the clinical implications and developing targeted treatments for MF in athletes are crucial areas for future research.
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