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Related Concept Videos

The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
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The skin aging exposome.

Jean Krutmann1, Anne Bouloc2, Gabrielle Sore3

  • 1IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.

Journal of Dermatological Science
|October 11, 2016
PubMed
Summary
This summary is machine-generated.

The exposome, encompassing all exposures from conception to death, impacts skin aging. This review defines the skin aging exposome and highlights research needs for protective strategies.

Keywords:
Air pollutionCosmetic strategiesInfrared radiationNutritionUltraviolet radiationVisible light

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Area of Science:

  • Environmental Medicine
  • Dermatology
  • Toxicology

Background:

  • The exposome concept broadly covers all environmental exposures influencing health.
  • Exposome research has largely overlooked the skin, lacking a specific definition for its aging factors.
  • Skin aging is a complex process influenced by numerous internal and external factors.

Purpose of the Study:

  • To define the skin aging exposome.
  • To review scientific evidence on exposome factors affecting skin aging.
  • To identify future research directions and protective strategies.

Main Methods:

  • Comprehensive literature review using PubMed.
  • Analysis of epidemiological, in vitro, ex vivo, and clinical studies.
  • Collaboration between environmental medicine and skin biology experts.

Main Results:

  • Key exposome factors influencing skin aging were identified.
  • A novel definition of the skin aging exposome is proposed.
  • Existing evidence linking exposome factors to skin aging was summarized.

Conclusions:

  • The skin aging exposome is a critical area for future research.
  • Understanding interactions between exposomal factors is essential.
  • Developing protective measures against skin aging exposome is recommended.