Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Self-Regulation01:25

Self-Regulation

308
Self-regulation, also known as self-control, encompasses a range of cognitive and behavioral processes that allow individuals to adjust their internal states and outward actions to align with socially acceptable norms and long-term goals. It plays a fundamental role in adaptive functioning, from resisting impulsive behaviors to persisting through challenging tasks. While its benefits are widely recognized, self-regulation is not limitless. Muraven and Baumeister's theory posits that...
308
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

4.8K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Methcathinone self-administration decreases dopamine and serotonin transporter function in rats.

Drug and alcohol dependence·2026
Same author

Advancing translational science through trial integrity: REDCap-based approaches to mitigating fraud and bias.

Journal of clinical and translational science·2026
Same author

Maximizing Engagement, Trust, and Clinical Benefit of AI-Generated Recovery Support Messages for Alcohol Use Disorder: Protocol for an Optimization Study.

JMIR research protocols·2025
Same author

Machine learning models for temporally precise lapse prediction in alcohol use disorder.

Journal of psychopathology and clinical science·2024
Same author

Clarifying the relationship between mental illness and recidivism using machine learning: A retrospective study.

PloS one·2024
Same author

Continuous renal replacement therapy and survival in acute liver failure: A systematic review and meta-analysis.

Journal of critical care·2024
Same journal

Chronic psilocin microdosing produces limited behavioral effects and does not enhance neurogenesis in rats.

Pharmacology, biochemistry, and behavior·2026
Same journal

Modulation of prefrontal NMDA receptors reveals pharmacogenetic differences between SHR and SLA16 rat strains.

Pharmacology, biochemistry, and behavior·2026
Same journal

Spontaneous oxycodone withdrawal alters behavior and oligodendrocyte-related gene expression in mice.

Pharmacology, biochemistry, and behavior·2026
Same journal

Improvement in depressive symptoms in people undergoing cognitive behavioral therapy who supplemented with probiotics: An open-label, pilot study.

Pharmacology, biochemistry, and behavior·2026
Same journal

Long-term follow-up of children with autism spectrum disorder and severe treatment-resistant behavioral symptoms treated with purified cannabidiol.

Pharmacology, biochemistry, and behavior·2026
Same journal

Fluoxetine reduces anxiety-like behavior but increases motor impairments in the early stages of a progressive model of Parkinson's disease.

Pharmacology, biochemistry, and behavior·2026
See all related articles

Related Experiment Video

Updated: Mar 13, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

11.2K

Acute bouts of wheel running decrease cocaine self-administration: Influence of exercise output.

Mark A Smith1, Gaylen E Fronk1, Huailin Zhang1

  • 1Department of Psychology, Program in Neuroscience, Davidson College, Davidson, NC 28035, USA.

Pharmacology, Biochemistry, and Behavior
|November 6, 2016
PubMed
Summary
This summary is machine-generated.

Acute exercise significantly reduces cocaine intake in female rats, with greater reductions seen after longer exercise durations. These findings highlight physical activity

Keywords:
CocaineExerciseRatSelf-administrationWheel

More Related Videos

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
10:28

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Published on: February 18, 2016

18.1K
Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats
09:43

Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats

Published on: October 5, 2021

3.1K

Related Experiment Videos

Last Updated: Mar 13, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

11.2K
Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
10:28

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Published on: February 18, 2016

18.1K
Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats
09:43

Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats

Published on: October 5, 2021

3.1K

Area of Science:

  • Behavioral Neuroscience
  • Neuropharmacology
  • Addiction Research

Background:

  • Exercise is linked to reduced drug use in humans and animals.
  • Limited research explores the impact of exercise intensity and duration on drug self-administration.
  • Understanding acute exercise effects is crucial for addiction treatment strategies.

Purpose of the Study:

  • To investigate the effects of acute exercise on cocaine self-administration.
  • To determine if exercise's impact on cocaine intake depends on exercise output (duration).
  • To assess the influence of the time interval between exercise and drug administration.

Main Methods:

  • Female rats were trained for cocaine self-administration using automated running wheels and intravenous catheters.
  • Rats underwent acute exercise (0, 30, or 60 minutes) immediately before cocaine self-administration tests.
  • Control tests included saline substitution and food-maintained responding to assess specificity.

Main Results:

  • Acute exercise dose-dependently decreased cocaine self-administration.
  • The most significant reduction in cocaine intake occurred after 60 minutes of exercise.
  • Exercise did not affect food-maintained responding or responding during saline substitution tests.

Conclusions:

  • Acute exercise, particularly longer durations, effectively reduces cocaine self-administration in a time- and output-dependent manner.
  • Physical activity may serve as a valuable component in comprehensive drug abuse treatment programs.
  • These findings support the role of exercise in mitigating drug-seeking behaviors.