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The effect of structurally related impurities on crystallinity reduction of sulfamethazine by grinding

Yoshito Hamada1, Makoto Ono2, Motomu Ohara2

  • 1Analytical and Quality Evaluation Research Laboratories, Daiichi Sankyo Co. Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan; Graduate School of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan.

International Journal of Pharmaceutics
|November 6, 2016
PubMed

Keywords:
Crystallinity reductionEffect of impurityGrindingRaman spectroscopySulfamethazine

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