Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

5.9K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.9K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

4.0K
4.0K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.4K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.4K
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.8K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.8K
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

2.2K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
2.2K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

6.3K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aneuploidy selects for the acquisition of driver genes in breast cancer.

Nature·2026
Same author

The Hippo Pathway in Intestinal Regeneration, Fetal Reprogramming, and Tumorigenesis.

Cold Spring Harbor perspectives in biology·2026
Same author

OC43 clinical isolate spike proteins have distinct carbohydrate-binding properties.

Nature communications·2026
Same author

NOD2 drives regenerative fetal-like reprogramming in the intestinal epithelium.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer.

European journal of medicinal chemistry·2026
Same author

Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets.

Nature biotechnology·2025

Related Experiment Video

Updated: Mar 13, 2026

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.6K

KATapulting toward Pluripotency and Cancer.

Calley L Hirsch1, Jeffrey L Wrana2, Sharon Y R Dent3

  • 1Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada.

Journal of Molecular Biology
|October 11, 2016
PubMed
Summary

Lysine acetyltransferase (KAT) enzymes are emerging as key drivers of cellular plasticity. These enzymes are involved in reprogramming cell identity during somatic cell reprogramming and in tumor development.

Keywords:
acetylationembryonic stem cellshistoneplasticityreprogramming

More Related Videos

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model
05:08

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

Published on: February 17, 2019

6.7K
In vitro Enrichment of Ovarian Cancer Tumor-initiating Cells
11:37

In vitro Enrichment of Ovarian Cancer Tumor-initiating Cells

Published on: February 18, 2015

14.3K

Related Experiment Videos

Last Updated: Mar 13, 2026

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.6K
Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model
05:08

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

Published on: February 17, 2019

6.7K
In vitro Enrichment of Ovarian Cancer Tumor-initiating Cells
11:37

In vitro Enrichment of Ovarian Cancer Tumor-initiating Cells

Published on: February 18, 2015

14.3K

Area of Science:

  • Cellular biology
  • Epigenetics
  • Biochemistry

Background:

  • Cellular development is typically a one-way process establishing specialized cell fates.
  • Cellular identity is maintained by chromatin modifications and gene expression, but can be lost during injury or cancer.
  • Terminally differentiated cells can regain pluripotency, indicating inherent cellular plasticity.

Purpose of the Study:

  • To explore the role of lysine acetyltransferase (KAT) enzymes in cellular plasticity.
  • To investigate the involvement of KAT enzymes in somatic cell reprogramming and tumorigenesis.

Main Methods:

  • The study focuses on the emerging concept of KAT enzymes driving cellular plasticity.
  • The research explores the context of somatic cell reprogramming and tumorigenesis.

Main Results:

  • Lysine acetyltransferase (KAT) enzymes are implicated in driving cellular plasticity.
  • These enzymes play a role in the reorganization of chromatin, which is crucial for establishing new gene expression signatures and cell identity.

Conclusions:

  • Lysine acetyltransferase (KAT) enzymes are emerging as critical regulators of cellular plasticity.
  • Understanding the function of KAT enzymes in reprogramming and tumorigenesis may offer new therapeutic strategies.