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Updated: Mar 13, 2026
In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
Published on: August 16, 2013
Accuracy and interobserver agreement of diffusion-weighted imaging in pediatric inflammatory bowel disease
Zehour AlSabban1, Peter Church2, Rahim Moineddin3
1Department of Diagnostic Imaging, The Hospital For Sick Children and Medical Imaging, University Of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
Purpose:
To determine interobserver agreement (IOA) and accuracy of conventional MR enterography (MRE), qualitative diffusion, and apparent diffusion coefficient (ADC) values for detecting clinically active inflammation.
Methods:
MREs in 57 consecutive children with suspected inflammatory bowel disease were retrospectively reviewed.
Results:
Substantial IOA for conventional MRE (kappa=0.65) and qualitative diffusion (kappa=0.64), but fair to good IOA for ADC, (intra-class coefficient=0.63) were seen. Conventional MRE detected active clinical inflammation well (area under curve [AUC] 0.725), while qualitative diffusion and ADC did not perform well (AUC=0.572 and 0.461, respectively).
Conclusion:
DWI can be helpful in diagnosing inflammatory bowel disease but does not perform well in identifying those with active inflammation.
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