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Updated: Aug 10, 2026

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Induction and Testing of Hypoxia in Cell Culture
Published on: August 12, 2011
Some factors affecting the specific toxicity of misonidazole towards hypoxic mammalian cells
The British Journal of Cancer. Supplement
|June 1, 1978
Abstract:
The toxic action of misonidazole towards hypoxic mammalian cells has been shown to be a function of serum concentration, with higher serum concentrations enhancing the toxic effect. Added thiols protect cells against misonidazole toxicity. In addition, the action of misonidazole on hypoxic cells labelled with 5-BUdR has been examined. Cells with incroported 5-BUdR are no more sensitive to misonidazole toxicity than are cells without label.

