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Eperisone hydrochloride-induced maculopapular rash.
Namrata Balaraddiyavar1, Aruna Bhushan1, Basavaraj C Kotinatot1
1Department of Pharmacology, BIMS, Belgaum, Karnataka, India.
Indian Journal of Pharmacology
|October 11, 2016
Summary
A 30-year-old male experienced a severe rash after taking eperisone hydrochloride for pain. This is the first reported case of hypersensitivity to this analgesic and antispastic drug in India.
Area of Science:
- Pharmacology
- Clinical Medicine
- Dermatology
Background:
- Eperisone hydrochloride is an analgesic and antispastic medication.
- It is widely used in Asian countries, including India, for conditions like spastic paralysis and cervical spondylosis.
- The drug is not officially licensed in India.
Observation:
- A 30-year-old male patient developed a severe maculopapular rash.
- The rash appeared after the patient was prescribed eperisone hydrochloride for body pain and loose stools.
- This adverse drug reaction was noted despite the drug's common use.
Findings:
- This case represents the first documented instance of hypersensitivity to eperisone hydrochloride in India.
- Previous studies have indicated a history of hypersensitivity to this drug in other countries.
- The patient's symptoms suggest a significant adverse drug reaction.
Implications:
- This report highlights the potential for severe cutaneous adverse drug reactions to eperisone hydrochloride.
- It underscores the importance of pharmacovigilance, especially for drugs not fully licensed in a region.
- Further investigation into the safety profile and hypersensitivity potential of eperisone hydrochloride in the Indian population is warranted.
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