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Updated: Mar 13, 2026
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Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging
Published on: November 19, 2012
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Optical Coherence Tomography for Brain Imaging and Developmental Biology
Jing Men1, Yongyang Huang1, Jitendra Solanki1
1Department of Electrical and Computer Engineering, Center for Photonics and Nanoelectronics, and Bioengineering Program, Lehigh University, Bethlehem, PA, USA, 18015.
IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-Optics Society
|October 11, 2016
Summary
Optical coherence tomography (OCT) advances brain imaging and developmental biology. This study explores OCT
Area of Science:
- Biomedical Engineering
- Developmental Biology
- Neuroscience
Background:
- Optical coherence tomography (OCT) is a high-resolution, 3D imaging technique.
- OCT offers label-free, non-invasive visualization of biological tissues.
- Its applications span brain imaging and developmental biology research.
Purpose of the Study:
- To review various applications of OCT in brain imaging and developmental biology.
- To investigate the impact of circadian genes and high-fat diets on heart development.
- To elucidate mechanisms linking circadian rhythms and obesity to cardiac health.
Main Methods:
- Utilized optical coherence tomography (OCT) for volumetric imaging.
- Employed *Drosophila melanogaster* as a model organism.
- Investigated the effects of the *Clock* gene and high-fat diet on heart development.
Main Results:
- Demonstrated OCT's capability for high-resolution, longitudinal *in vivo* imaging.
- Identified specific effects of circadian gene disruption and high-fat diet on heart development in *Drosophila*.
- Provided insights into the interplay between circadian genes, diet, and cardiac development.
Conclusions:
- OCT is a powerful tool for studying complex biological processes like heart development.
- Circadian gene function and dietary factors significantly influence cardiac development.
- Findings contribute to understanding the etiology of heart diseases related to circadian disruption and obesity.
Keywords:
Biological systemsBiomedical optical imagingBrainCardiovascular system and Optical tomographyMore Related Videos
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