Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

530
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
530
Heart Valves01:16

Heart Valves

13.2K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
13.2K
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

493
Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
493
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

1.1K
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
1.1K
Mitral Regurgitation IV: Nursing Management01:28

Mitral Regurgitation IV: Nursing Management

476
Mitral regurgitation (MR) is a condition where the mitral valve does not close properly, leading to the backward flow of blood from the left ventricle into the left atrium during systole. This condition can arise from various causes, including rheumatic fever, infective endocarditis, or degenerative valve disease. Effective nursing management is crucial to optimizing patient outcomes and involves comprehensive assessment and targeted interventions.Comprehensive Patient AssessmentA detailed...
476
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

833
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
833

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Small Diameter Vascular Grafts Made in Minutes.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Cardiovascular stent technologies for coronary and valvular heart disease: the potential of 3D printing for stent fabrication.

Nature reviews. Cardiology·2026
Same author

MSC Origin and Biomechanical Conditioning Determine ECM Maturation in Tissue-Engineered Matrix.

Biomedicines·2026
Same author

A vertically integrated system for tracking and assessing cell-cycle-aware phenotypes under confinement.

APL bioengineering·2026
Same author

Model Choice and Interpretation in Coronary Tissue Engineering: Still More Questions Than Answers?

JACC. Basic to translational science·2026
Same author

Combining genome and tissue engineering for next-generation human biomimetics.

Stem cells translational medicine·2025

Related Experiment Video

Updated: Mar 13, 2026

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

3.5K

Heart Valve Replacements with Regenerative Capacity.

Petra E Dijkman1, Emanuela S Fioretta1, Laura Frese1

  • 1Institute for Regenerative Medicine (IREM), University of Zurich, Zurich, Switzerland.

Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur Transfusionsmedizin Und Immunhamatologie
|October 11, 2016
PubMed
Summary

Tissue engineering offers innovative solutions for growing heart valves, addressing limitations of current replacements. These regenerative valves show promise in preclinical and clinical studies for improved patient outcomes.

Keywords:
BiomaterialsDecellularized tissuesHeart valve prosthesisHeart valvesRegenerative medicineScaffoldsTissue engineeringTranscatheter aortic valve replacement

More Related Videos

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
11:12

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves

Published on: October 17, 2013

14.3K
Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

14.8K

Related Experiment Videos

Last Updated: Mar 13, 2026

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

3.5K
Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
11:12

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves

Published on: October 17, 2013

14.3K
Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

14.8K

Area of Science:

  • Regenerative medicine
  • Biomaterials science
  • Cardiovascular engineering

Background:

  • Severe valvular dysfunction is rising, necessitating over 300,000 valve implantations annually.
  • Current artificial heart valves cannot grow, leading to repeat surgeries in pediatric patients.
  • Tissue-engineered heart valves (TEHVs) aim to overcome these limitations with regenerative solutions.

Approach:

  • Review of diverse TEHV strategies including in vitro, in situ, and in vivo methods.
  • Focus on the pre-seeding approach for enhanced valve integration and remodeling.
  • Exploration of clinical translation pathways for regenerative valves.

Key Points:

  • TEHVs demonstrate successful integration and remodeling in preclinical models.
  • Promising results observed in early-stage clinical studies for regenerative valves.
  • Successful clinical adaptation requires addressing technical, clinical, and regulatory challenges.

Conclusions:

  • Tissue engineering presents a viable alternative to conventional heart valve replacements.
  • Regenerative valves hold significant potential for pediatric and adult cardiovascular care.
  • Further research and development are crucial for commercialization and widespread clinical adoption.