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Updated: Mar 13, 2026
The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
Published on: June 1, 2019
Breast Cancer Sentinel Node Detection: An Alternative Solution for Centers Lacking Nuclear Technology
Mahmoud A Alhussini1, Ahmed T Awad1, Mohamed H Ashour2
1Surgical Oncology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt, Alexandria, Egypt.
Background:
Sentinel lymph node (SLN) has become the gold standard for all cases with no axillary nodal metastasis. The combined radioisotope and blue dye technique is adopted in most centers. The lack of the technology for radioisotope in our institution encouraged us to study the feasibility of methylene blue (MB) for SLN detection in breast cancer patients admitted to Alexandria Surgical Oncology Unit.
Methods:
A total of 144 cases were subjected to SLN detection by injecting 2 ml of MB 1%. This was followed by standard axillary lymph node dissection. The safety and accuracy of MB as a tracer for detection of SLN were studied.
Results:
The identification rate was 93.15%. The number of SLN identified ranged from 1 to 8 nodes with a mean of 1.75 ± 1.17. The sensitivity of MB dye technique was 96.3%. The false negative rate was 3.7%. The negative predictive value was 97.6% and the accuracy was 98.5%.
Conclusions:
MB is a safe, reliable, cheap, and accurate alternative tracer for detection of SLN.
