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Systemic Therapy of Advanced/Metastatic Breast Cancer - Current Evidence and Future Concepts

Cornelia Liedtke1, Hans-Christian Kolberg2

  • 1Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein/Campus Lübeck, Lübeck, Germany.

Breast Care (Basel, Switzerland)
|October 11, 2016
PubMed

Insights

Systemic therapy for metastatic breast cancer involves chemotherapy, endocrine, and targeted treatments. Characterizing the cancer subtype is crucial for selecting the most effective treatment approach.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Metastatic breast cancer treatment requires tailored systemic therapies.
  • Therapeutic options include chemotherapy, endocrine therapy, and targeted agents.

Approach:

  • Disease phenotype characterization via biopsy is essential for treatment selection.
  • Combination therapies are utilized based on specific breast cancer subtypes.

Key Points:

  • Novel treatments under investigation include immunologic therapies, PARP inhibitors, PI3K inhibitors, and CDK4/6 inhibitors.
  • These emerging therapies are currently being evaluated in clinical trials.

Conclusions:

  • Personalized treatment strategies are key for managing metastatic breast cancer.
  • Ongoing research aims to expand therapeutic options for advanced disease.
Keywords:
ChemotherapyClinical trialsEndocrine therapyMetastatic breast cancerMolecular breast cancer subgroupsTargeted therapy

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