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Related Experiment Videos

Urinary bladder neoplasms: evaluation with contrast-enhanced MR imaging.

J M Neuerburg1, K Bohndorf, M Sohn

  • 1Department of Diagnostic Radiology, University of Aachen, Medical Faculty, Federal Republic of Germany.

Radiology
|September 1, 1989
PubMed
Summary

Gadolinium diethylene-triaminepentaacetic acid (DTPA) significantly enhances magnetic resonance imaging signal intensity in urinary bladder neoplasms. This contrast agent improves tumor visibility and detection of necrotic tissue.

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Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • Urinary bladder neoplasms require accurate diagnostic imaging.
  • Magnetic resonance imaging (MRI) is a key modality for evaluating these tumors.
  • Contrast enhancement can improve lesion detection and characterization.

Purpose of the Study:

  • To evaluate the efficacy of gadolinium diethylene-triaminepentaacetic acid (Gd-DTPA) in enhancing MRI signal intensity of urinary bladder neoplasms.
  • To assess the impact of Gd-DTPA on tumor visibility and detection of intratumoral necrosis.

Main Methods:

  • Forty-eight patients with urinary bladder neoplasms underwent MRI before and after intravenous Gd-DTPA administration.
  • Spin-echo and gradient-echo sequences were utilized.
  • Signal intensity ratios (tumor to fat, muscle, bone marrow) were calculated on T1-weighted images.

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Main Results:

  • Gd-DTPA administration resulted in a statistically significant increase in tumor signal intensity on T1-weighted spin-echo images (P < .0001).
  • Average relative signal intensity increases were 120% (tumor-fat), 105% (tumor-marrow), and 85% (tumor-muscle).
  • Tumor signal intensity peaked within 120 seconds and plateaued for up to 45 minutes. Necrotic tissue was detectable only post-enhancement.

Conclusions:

  • Gd-DTPA significantly enhances MRI signal intensity in urinary bladder neoplasms.
  • Contrast-enhanced MRI improves tumor conspicuity and aids in the detection of intratumoral necrosis.
  • Gd-DTPA is a valuable tool for the MR imaging evaluation of bladder tumors.