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Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs
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Diastolic Dyssynchrony in Acute ST Segment Elevation Myocardial Infarction and Relationship with Functional Recovery

Burak Turan1, Tolga Daşli1, Ayhan Erkol1

  • 1Cardiology Department, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey.

Journal of Cardiovascular Ultrasound
|October 11, 2016
PubMed

Insights

ST-elevation myocardial infarction disrupts left ventricular diastolic synchrony. However, diastolic dyssynchrony in the acute phase is linked to better left ventricular functional recovery and reduced remodeling post-STEMI.

Area of Science:

  • Cardiology
  • Cardiac Imaging
  • Myocardial Infarction

Background:

  • Diastolic dyssynchrony (DD) incidence and impact on left ventricle (LV) recovery post-ST-elevation myocardial infarction (STEMI) remain unclear.
  • Assessing DD is crucial for understanding LV functional outcomes after acute cardiac events.

Purpose of the Study:

  • To investigate the incidence of diastolic dyssynchrony (DD) in patients with ST-elevation myocardial infarction (STEMI).
  • To evaluate the impact of DD on left ventricular (LV) functional recovery and remodeling after STEMI.

Main Methods:

  • Prospective enrollment of STEMI patients undergoing successful revascularization.
  • Echocardiography with tissue Doppler imaging within 48 hours and at 6 months to assess LV volumes, ejection fraction, and diastolic delay (TeDiff).
  • Comparison of STEMI patients with a demographically matched control group.

Main Results:

  • STEMI patients exhibited higher TeDiff and DD incidence compared to controls (p=0.025 and p=0.046, respectively).
  • TeDiff positively correlated with improved ejection fraction at 6 months (r=0.328, p=0.023).
  • Patients with baseline DD showed less LV remodeling at follow-up (11% vs. 38%, p=0.040).

Conclusions:

  • STEMI significantly disrupts LV diastolic synchronicity.
  • Acute-phase DD in STEMI is associated with better subsequent LV functional recovery.
  • DD may indicate salvageable peri-infarct myocardium and is linked to infarct size, influencing remodeling.
Abstract

Keywords:
Diastolic dyssynchronyMyocardial infarctionRemodeling

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