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Correlation between CMV Infection and Post-transplantation New-onset Diabetes Mellitus
I Dedinská1, Ľ Laca1, J Miklušica1
1Surgery Clinic and Transplant Center, University Hospital Martin and Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic.
Background:
New-onset diabetes mellitus after transplantation (NODAT) is a well-known complication of transplantation.
Objective:
To determine the correlation between CMV infection and NODAT.
Methods:
Retrospectively, we detected CMV replication (PCR) in every month after renal transplantation in the first 12 months of the procedure in a homogenous group of patients from the immunosuppression point of view.
Results:
In 167 patients (64 with NODAT and 103 in the control group), the average amount of CMV viremia was not significantly different between the NODAT and the control group (p=0.929). In the 10th month of transplantation, we recorded a significantly higher CMV viremia in the NODAT group (p<0.0001), however, in the multivariant analysis, the observed statistical difference vanished. The survival of patients and grafts was 12 months after kidney transplantation without any statistically significant difference between the studied groups (p=0.611 and p=0.538, respectively).
Conclusion:
CMV is not a risk factor for NODAT.
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