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Updated: Mar 13, 2026
Murine Full-thickness Skin Transplantation
Published on: January 2, 2017
Human Split-Thickness Skin Allograft from Brain-Dead Donors
A Khodadadi1, O Olang2, A Makhllough3
1Iranian Tissue Bank Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Background:
Looking for an appropriate skin substitute for temporary and permanent coverage of wounds remains one of the main obstacles of medical researchers.
Objective:
To investigate the rate of inflammation, symbiosis, and survival of grafted allograft skin from brain-dead donors (BDDs) in rabbits.
Methods:
After receiving negative serologic tests of BDDs, we prepared partial thickness skin grafts. They were then used in treating wounds of 5 rabbits in comparison with split-thickness skins taken from cardiac dead donors.
Results:
On histopathological examinations, we found no difference between the skins. All samples were separated from the baseline in 15-20 days.
Conclusion:
Gamma-irradiated freeze-dried human split-thickness skin taken from BDDs is safe and can be used for the treatment of deep skin burns.
