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Related Experiment Video

Updated: Mar 13, 2026

Murine Full-thickness Skin Transplantation
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Human Split-Thickness Skin Allograft from Brain-Dead Donors.

A Khodadadi1, O Olang2, A Makhllough3

  • 1Iranian Tissue Bank Research Center, Tehran University of Medical Sciences, Tehran, Iran.

International Journal of Organ Transplantation Medicine
|October 11, 2016
PubMed
Summary

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Grafted skin from brain-dead donors (BDDs) showed no significant difference in healing compared to skin from cardiac-dead donors. This suggests BDD skin is a viable option for treating deep skin burns.

Area of Science:

  • Regenerative Medicine
  • Wound Healing
  • Transplantation Immunology

Background:

  • Finding suitable skin substitutes for wound coverage is a significant challenge in medical research.
  • Allograft skin transplantation is a critical area for treating severe skin injuries.
  • The use of skin from brain-dead donors (BDDs) requires thorough investigation regarding its viability and integration.

Purpose of the Study:

  • To evaluate the inflammatory response, symbiotic integration, and survival rates of allograft skin grafts from BDDs in a rabbit model.
  • To compare the efficacy of skin grafts from BDDs with those from cardiac-dead donors for wound treatment.

Main Methods:

  • Partial-thickness skin grafts were prepared from BDDs following negative serologic testing.
  • Grafts were applied to wounds in 5 rabbits and compared against split-thickness skin grafts from cardiac-dead donors.
Keywords:
Biological dressingsGraftGraft rejectionInflammationSurvivalSymbiosis

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  • Histopathological examinations were conducted to assess graft integration and tissue response.

    • Main Results:

    • Histopathological analysis revealed no significant differences between skin grafts from BDDs and cardiac-dead donors.
    • All skin graft samples demonstrated separation from the baseline wound within 15-20 days post-transplantation.
    • No significant variations in inflammation or symbiosis were observed between the two donor groups.

    Conclusions:

    • Gamma-irradiated, freeze-dried human split-thickness skin from BDDs is safe for clinical application.
    • Skin grafts from BDDs can be effectively utilized for the treatment of deep skin burns.
    • The study supports the potential of utilizing BDDs as a source for skin grafts in reconstructive surgery.