Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

735
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
735
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

821
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
821
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

687
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
687
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

294
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
294
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

895
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
895
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

871
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
871

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Financial burden of systemic lupus erythematosus in India: prevalence and predictors of catastrophic health expenditure in a multicentre cross-sectional study.

BMC rheumatology·2025
Same author

Awareness, perspectives and satisfaction levels among patients with psoriatic arthritis: a multicentric cross-sectional survey.

Rheumatology international·2023
Same author

Impact of COVID-19 pandemic on patients with SLE: results of a large multicentric survey from India.

Annals of the rheumatic diseases·2020
Same author

Abdominal Vascular Injury During Posterior Lumbar Discectomy, Experience from Three Cases and Review of Literature.

Spine·2019
Same author

Carcinoma en cuirasse in a young female.

BMJ case reports·2017
Same author

Pediatric conjoint Hoffa's fracture: An uncommon injury and review of literature.

Journal of clinical orthopaedics and trauma·2017
Same journal

Correction to: Challenges in diagnosing confluent and reticulated papillomatosis: a case of atypical lesions distribution.

Oxford medical case reports·2026
Same journal

Cutaneous Rosai-Dorfman-Destombes disease: the diagnostic value of the yellow island sign.

Oxford medical case reports·2026
Same journal

Central serous chorioretinopathy following intramuscular testosterone therapy in prolactinoma.

Oxford medical case reports·2026
Same journal

Neuropsychiatric-pharmacologic synergy: interaction between psychiatric polypharmacy and cancer treatment-related neurotoxicity.

Oxford medical case reports·2026
Same journal

A case of surgically treated recurrent spontaneous pneumothorax during pregnancy.

Oxford medical case reports·2026
Same journal

Vaping-associated acute respiratory distress syndrome managed with VV-ECMO: a case report.

Oxford medical case reports·2026
See all related articles

Related Experiment Video

Updated: Mar 13, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

7.7K

Polyarteritis nodosa with a chronic relapsing course.

Ashok Kumar1, Anshul Goel1, Mehul Lapsiwala1

  • 1Department of Rheumatology, Fortis Flt Lt Rajan Dhall Hospital , New Delhi   110070 , India.

Oxford Medical Case Reports
|October 11, 2016
PubMed
Summary
This summary is machine-generated.

This case study highlights a rare, prolonged presentation of polyarteritis nodosa (medium artery vasculitis) in a young adult, leading to severe organ damage. Despite aggressive treatment, the patient succumbed to complications arising from immunosuppressive therapy.

Keywords:
Chronic polyarteritis nodosaIndolent polyarteritis nodosaPANRelapsing polyarteritis nodosa

More Related Videos

Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

137.7K
Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
09:29

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

12.1K

Related Experiment Videos

Last Updated: Mar 13, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

7.7K
Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

137.7K
Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
09:29

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

12.1K

Area of Science:

  • Rheumatology
  • Immunology
  • Vascular Medicine

Background:

  • Polyarteritis nodosa is a serious medium artery vasculitis.
  • It typically presents acutely but can have a chronic, relapsing course.
  • Early diagnosis and treatment are crucial to prevent organ damage and mortality.

Observation:

  • A 24-year-old patient experienced 16 years of recurrent vasculitic episodes.
  • The most recent episode caused severe complications including mononeuritis multiplex, digital and bowel gangrene with perforations.
  • Diagnosis was challenging, requiring CT angiography to identify mesenteric artery aneurysms.

Findings:

  • The patient survived extensive organ infarction and bowel perforation surgery.
  • Treatment with corticosteroids, IV immunoglobulin, and cyclophosphamide was poorly tolerated or ineffective.
  • The patient ultimately died from a cerebellar abscess secondary to immunosuppressive therapy.

Implications:

  • This case underscores the diagnostic challenges of chronic polyarteritis nodosa.
  • It highlights the potential for severe, life-threatening complications even with treatment.
  • The case also illustrates the risks associated with immunosuppressive therapy in vasculitis management.