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A biotin-guided formaldehyde sensor selectively detecting endogenous concentrations in cancerous cells and tissues
Yun Hak Lee1, Yonghe Tang2, Peter Verwilst1
1Department of Chemistry, Korea University, Seoul 136-701, Korea. jongskim@korea.ac.kr.
Abstract:
A biotin appended formaldehyde sensor was found to specifically visualise both exogenous and endogenous levels of formaldehyde in biotin receptor positive cells over biotin negative cells by means of one- and two-photon excitation. The probe furthermore visualised endogenous levels of formaldehyde in tumour tissue slices up to 70 μm depth.

