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Updated: Mar 13, 2026

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Published on: November 17, 2015

Lipid-based nanovesicles for nanomedicine.

N Grimaldi¹, F Andrade², N Segovia²

¹Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus Universitari de Bellaterra, 08193, Cerdanyola del Vallès, Spain. vecianaj@icmab.es ventosa@icmab.es and Nanomol Technologies SA, Módul de Recerca B, Campus Universitari de Bellaterra, 08193, Cerdanyola del Vallès, Spain.

Chemical Society Reviews

|October 11, 2016

Summary

New non-liposomal lipid-based nanovesicles (L-NVs) offer advantages over traditional liposomes for drug delivery. Compressed fluid technologies show promise for scalable L-NV production, advancing nanomedicine towards clinical applications.

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Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

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Area of Science:

Nanomedicine and advanced drug delivery systems.
Focus on lipid-based nanovesicles (L-NVs) for therapeutic applications.

Background:

Liposomes, the first generation of L-NVs, are established drug carriers but face challenges like poor stability and high production costs.
Non-liposomal L-NVs represent a newer generation with potential to overcome liposome limitations.

Approach:

Review of diverse L-NVs, emphasizing novel non-liposomal designs.
Exploration of current and cutting-edge L-NV production methods, particularly compressed fluid technologies.
Discussion of L-NV applications and future perspectives in nanomedicine.

Key Points:

Non-liposomal L-NVs offer enhanced properties compared to traditional liposomes.
Compressed fluid technologies are highlighted as a scalable and efficient production method.
L-NVs show significant potential for clinical translation and market entry.

Conclusions:

Non-liposomal L-NVs are poised to advance nanomedicine by addressing limitations of current liposomal formulations.
Scalable production methods like compressed fluid technology are crucial for the successful transition of L-NVs from research to market.
Further development and clinical evaluation are necessary to fully realize the potential of this new generation of nanovesicles.