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Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
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Specific enrichment combined with highly efficient solid-phase tagging for the sensitive detection of heparin based
1School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.
Chemical Communications (Cambridge, England)
|October 11, 2016
Abstract:
A combined specific enrichment and highly efficient solid-phase tagging approach is presented for heparin detection using boronic acid-functionalized mesoporous silica nanospheres as extraction sorbents and nanoscale reactors. It exhibits a faster reaction time (only 6 min), higher tagging-product purity and lower applicable sample concentration compared with liquid-phase tagging.
