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Conventional BODIPY Conjugates for Live-Cell Super-Resolution Microscopy and Single-Molecule Tracking
Published on: June 8, 2020
Benzothiazole-pyrimidine-based BODIPY analogues: promising luminophores with fluorescence sensing and imaging ability
Xiaoqing Wang1, Qingsong Liu2, Fen Qi3
1Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, P.R. China. iamzpliu@njtech.edu.cn chliuzp@163.com iamwhuang@njtech.edu.cn and Institute of Advanced Synthesis (IAS), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, P.R. China.
Abstract:
A new family of BODIPY analogues (BDB1-8) derived from benzothiazole-pyrimidine-based bidentate ligands was synthesized and fully characterized. The photophysical properties of these boron complexes were measured both in solution and solid-state. These new luminophores exhibited intense fluorescence with high quantum yields ranging from 0.27 to 0.79, and moderate Stokes shifts ranging from 660 to 2120 cm-1 in solution. Due to the existence of strong intermolecular interactions, BDB1-8 showed quenched fluorescence with low quantum yields ranging from 0.03 to 0.20 in solid-state. In addition, BDB1 and BDB2 were capable of sensing cysteine in aqueous solution with high selectivity and sensitivity, which means that these complexes hold great potential in serving as fluorogenic cysteine sensors for biological application.
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