Related Experiment Video
Updated: Mar 13, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Bis[alkynylplatinum(ii)] terpyridine molecular tweezer with conformationally-rigid spacer: modulating the binding
Zijian Li1, Yifei Han1, Fan Jin1
1CAS Key Laboratory of Soft Matter Chemistry, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China. drfwang@ustc.edu.cn.
Abstract:
A novel bis[alkynylplatinum(ii)] terpyridine molecular tweezer with conformationally-rigid spacer has been designed and synthesized, which shows enhanced binding affinity towards the complementary guests when compared to its semi-rigid counterpart. Moreover, a three-component supramolecular recognition system comprised of the molecular tweezer and two electron-rich guests was established. Reversible switching of the host-guest binding preference can be achieved via adding a trace amount of hexafluoroisopropanol (HFIP) into chloroform. Such a system will be interesting for the future construction of intelligent molecular machines and devices.
More Related Videos
09:04Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
09:34Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Related Concept Videos
Stereoisomerism
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Valence Bond Theory
Hybridization of Atomic Orbitals II
Ligand Binding and Linkage
Chirality at Nitrogen, Phosphorus, and Sulfur
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
Hybridization of Atomic Orbitals I