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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
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Metabolomics, Lipidomics and Pharmacometabolomics of Human Hypertension

Anthony Au1, Kian-Kai Cheng2,3, Loo Keat Wei4,5

  • 1Institute of Bioproduct Development and Department of Bioprocess Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81300, Johor, Malaysia. auzlanthony@gmail.com.

Advances in Experimental Medicine and Biology
|October 11, 2016
PubMed

Insights

Metabolomics offers key insights into hypertension, a complex disease. This approach helps identify biomarkers for better diagnosis, treatment prediction, and monitoring of drug effectiveness in hypertension management.

Area of Science:

  • Biochemistry
  • Genetics
  • Medicine

Background:

  • Hypertension is a prevalent, multifactorial human disease with serious complications like heart attack and stroke.
  • Understanding the heterogeneous pathogenesis of hypertension requires advanced molecular investigation.

Purpose of the Study:

  • To review the application of metabolomics in understanding human hypertension.
  • To highlight the role of metabolomics in discovering disease-specific biomarkers.

Main Methods:

  • Review of recent metabolomic, lipidomic, and pharmacometabolomic studies on hypertension.
  • Focus on identifying metabolic biomarkers for hypertension.

Main Results:

  • Metabolomic studies have enhanced the identification of hypertension biomarkers.
  • These studies offer insights into predicting treatment outcomes.
  • Metabolomics aids in monitoring drug safety and efficacy.

Conclusions:

  • Metabolomics is crucial for elucidating the molecular mechanisms of hypertension.
  • Metabolic biomarker discovery is a key application of metabolomics in hypertension research.

Keywords:
HypertensionLipidomicsMetabolomicsPharmacometabolomics

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